Bonacina started learning music at the age of eight. She got classical saxophone lessons at various conservatories in Belfort, Besançon and Paris.
Between 1996 and 1998, Bonacina played baritone saxophone in various jazz big bands in Paris. She then moved to Réunion, for seven years to teach saxophone at the Conservatoire National de Région During this time, she participated at numerous festivals in the Indien Oceans region. She was musically influenced of the inclusion of the living rhythms there, and this is reflected in her later compositions. Returning to Paris, her debut album Vue d'en Haut was released in 2005.
Bonacina has collaborated with musicians such as the French pianist Laurent de Wilde, Cuban pianist Omar Sosa, vibraphonist Mike Mainieri, saxophonist Andy Sheppard and guitarists Yannick Robert and Nguyên Lê