Frank began playing guitar at age 7 in Canberra, Australia where he was born and raised. He was influenced by the blues playing of Jimi Hendrix , John Mayall / Eric Clapton, and Grateful Dead's Jerry Garcia . In his mid-teens he discovered Steely Dan, The Brecker Brothers and Chick Corea, which pointed him in a jazzy direction. In 1982 at 23 he decided to leave his home to study at the Guitar Institute of Technology (GIT) in Hollywood. He graduated with the highest honor, Student of the Year and was offered a teaching position which he kept for 4 years. During that time he was playing the local jazz club circuit with his own band and already had his first book "Speed Picking" published. In 1986 he signe a 3 album contract with a small label called Legato and began his recording career.
The same year he was recruited by Jean-luc Ponty to tour. Shortly after that tour, he auditioned for Chick Corea and began a 6 year stint which culminated in 5 albums, a Grammy award and two Grammy Nominations. Chick helped expose Frank to the world, for which he is very grateful, "playing with Chick was like a dream come true" says Frank. That same year Ibanez guitars approached him to endorse their guitar which culminated in a long relationship and spawned the Frank Gambale model guitar which was first on sale worldwide in 1987. They made 4 versions of the guitar, the FGM100, FGM200, FGM300 and FGM400.
In 1987 Frank signed a 3-video deal with DCI / Warner Brothers for instructional videos. In 1988, Frank signed a major label deal with JVC. In 1990 he released "Thunder From Down Under" which sold well all over the world and at one point it was #1 on the Japanese Jazz charts along with all his three Legato releases in the top 10 at the same time.
In 1992, Frank decided it was time to go out there on his own and has been touring with his group ever since. He has toured in many countries with his own band including Brazil, Argentina, Chile, Australia, Germany, Switzerland, Japan and the U.S. He has done countless seminars and master classes worldwide to countries as far away as South Africa and Uruguay.
In 1996 Frank was offered a position of Head of the Guitar Department of a new musical school in the Los Angeles area called the L.A. Music Academy (LAMA). He wrote the core curriculum/ study program for this one year vocational school including Harmony and Theory, Improvisation, Technique and Composition courses. The school is a great success and is an inspirational place for guitarists the world over. He teaches one, sometimes 2 full day a week at the school when he is in town and maintains the guitar department, and chose the teachers.